The Sapphire PURE Mini E350 uses the AMD Socket FM1 CPU socket. Any compatible AMD CPU will have the same socket entry. It uses the DDR3 memory type, with maximum speeds of up to 1066 MHz, and 2 DDR3 slots allowing for a maximum total of 8 GB RAM.

The Mini-ITX form factor is common for low-power system builds. Lower power requirements allow for less cooling, which in turn means a quieter PC. As such, the Sapphire PURE Mini E350 may be ideal for activities that require minimal sound excess, such as watching movies. For a gaming PC, a traditional ATX form factor is recommended, which would be more generally compatible and would provide more expansion options than Mini-ITX, but Mini-ITX is still a solid choice.

The Sapphire PURE Mini E350 has 5 SATA 3.0 hard drive slots. These allow for theoretical data transfer speeds of up to 6GB/s, as opposed to the 3GB/s of SATA 2.0. Generally speaking, only high performance hard drives, specifically solid-state drives, will be able to take advantage of the bandwidth potential of SATA 3.0 ports, though it is backwards compatible, so you do not have to take advantage.

The Sapphire PURE Mini E350 supports onboard graphics. This allows for integrated graphics when paired with a compatible CPU that supports them. Integrated graphics are a cheap alternative to using a graphics card, but should be avoided when frequently using modern applications or games that require intense graphical processing. There are 1 PCIe x16 slots on this motherboard. This means it is perfectly capable of accommodating the latest graphics cards, although it is important to try and use a graphics card with the same graphics card interface of PCIe v2.x, as anything below will not reach the motherboard's potential, and anything above will have its performance slashed to the bandwidth maximum of the Sapphire PURE Mini E350's PCIe v2.x. The Sapphire PURE Mini E350 does not support multiple graphics cards via Nvidia SLI or AMD Crossfire.

The Sapphire PURE Mini E350 has 8 USB 2.0 slots and 2 USB 3.0 slots. USB 3.0 slots are theoretically capable of data transfer speeds of up to 5 Gbit/s, which is over 10 times faster than the USB 2.0 top speed of 480 Mbit/s. Although USB 2.0 slots alone currently serve as well as ever, an upgrade would better future-proof your system as more USB 3.0 compatible peripherals emerge. USB 3.0 is also backwards compatible with USB 2.0, which means you do not even have to use the newer slot functionality if you do not wish to.