The Asus M3N-HDHDMI uses the AMD Socket AM2+ CPU socket. Any compatible AMD CPU will have the same socket entry. It uses the aging DDR2 memory type, with maximum speeds of up to 1066 MHz, and 4 DDR2 slots allowing for a maximum total of 8 GB RAM. DDR2 memory is exceptionally out of date, and considering how cheap DDR3 RAM is, using a motherboard with only DDR2 compatibility in a modern system build would be a very bad idea.

Conforming to the ATX standard, the Asus M3N-HDHDMI should fit into the majority of cases. ATX is the most common form factor, and as such has a high degree of compatibility with other components while providing a decent number of slots to widen your expansion options.

The Asus M3N-HDHDMI has 6 SATA 2.0 hard drive slots. These allow for data speeds of up to 3GB/s. SATA 2.0 is a very common standard, and despite the emergence of SATA 3.0 - whose potential is difficult to reach currently - SATA 2.0 remains a viable option.

The Asus M3N-HDHDMI supports onboard graphics. This allows for integrated graphics when paired with a compatible CPU that supports them. Integrated graphics are a cheap alternative to using a graphics card, but should be avoided when frequently using modern applications or games that require intense graphical processing. There are 2 PCIe x16 slots on this motherboard. This means it is perfectly capable of accommodating the latest graphics cards, although it is important to try and use a graphics card with the same graphics card interface of PCIe v2.x, as anything below will not reach the motherboard's potential, and anything above will have its performance slashed to the bandwidth maximum of the Asus M3N-HDHDMI's PCIe v2.x. The Asus M3N-HDHDMI supports up to 2 Nvidia SLI connected graphics cards for improved overall graphical performance at the cost of multiplied graphics-based power consumption as well as the price of the cards themselves.

The Asus M3N-HDHDMI has 12 USB 2.0 slots but no USB 3.0 slots. While USB 3.0 slots are so far by no means necessary, and with a plethora of USB 2.0 peripherals to choose from, the USB functionality on this motherboard should be fine. If planning on building a new system, a motherboard with USB 3.0 is likely to have a longer life cycle, however.