The Asus KCMA-D8 Opteron C32 uses the AMD Socket C32 CPU socket. Any compatible AMD CPU will have the same socket entry. It uses the DDR3 memory type, with maximum speeds of up to 1600 MHz, and 8 DDR3 slots allowing for a maximum total of 128 GB RAM. There is enough room for memory expansion to last any build with this motherboard an extremely long time.

Conforming to the ATX standard, the Asus KCMA-D8 Opteron C32 should fit into the majority of cases. ATX is the most common form factor, and as such has a high degree of compatibility with other components while providing a decent number of slots to widen your expansion options.

The Asus KCMA-D8 Opteron C32 does not support onboard graphics. Any system build that uses this motherboard therefore requires a separate graphics card, or a processor that has a GPU on the same die, such as AMD APU processors. There are 2 PCIe x16 slots on this motherboard. This means it is perfectly capable of accommodating the latest graphics cards, although it is important to try and use a graphics card with the same graphics card interface of VGA, as anything below will not reach the motherboard's potential, and anything above will have its performance slashed to the bandwidth maximum of the Asus KCMA-D8 Opteron C32's VGA. The Asus KCMA-D8 Opteron C32 does not support multiple graphics cards via Nvidia SLI or AMD Crossfire.

The Asus KCMA-D8 Opteron C32 has 4 USB 2.0 slots but no USB 3.0 slots. While USB 3.0 slots are so far by no means necessary, and with a plethora of USB 2.0 peripherals to choose from, the USB functionality on this motherboard should be fine. With so few slots, however, you would have to use a USB expansion hub. As such, we would highly recommend a different motherboard, preferably with USB 3.0 functionality as well.